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Crestor Side Effects

Crestor can result in serious injuries such as heart attacks and heart failure. Other side effects include cardiomyopathy (deterioration of the myocardium), rhabdomyolysis (breakdown of muscle fibers), and ventricular dysfunction.

Based on these and other serious side effects, in 2004, a consumer advocacy group filed a petition with the FDA, suggesting that Crestor be removed from the market. In addition, an article in the medical journal The Lancet criticized the marketing tactics used to introduce the drug, as well as the data supporting its efficacy.

Heart Attacks and Heart Failure

Heart failure and heart attacks occur when blood flow to a section of heart muscle becomes blocked. If the flow of blood isn’t restored quickly, the section of heart muscle becomes damaged from lack of oxygen and begins to die. The most common heart attack signs and symptoms are:

  • Chest discomfort or pain—uncomfortable pressure, squeezing, fullness, or pain in the center of the chest that can be mild or strong.
  • Upper body discomfort in one or both arms, the back, neck, jaw, or stomach.
  • Shortness of breath may occur with or before chest discomfort.
  • Other signs include nausea, vomiting, lightheadedness, fainting, or breaking out in a cold sweat.


Cardiomyopathy, which literally means "heart muscle disease," is the deterioration of the function of the heart muscle (myocardium). People with cardiomyopathy are often at risk of arrhythmia, sudden cardiac death, or both. Cardiomyopathy can often go undetected, making it especially dangerous to carriers of the disease.

There are three main types of cardiomyopathy — dilated, hypertrophic and restrictive — all of which affect your heart muscle. Cardiomyopathy makes it harder for your heart to pump blood and deliver it to the rest of your body.


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